Repozytorium
Wyszukaj
Kolekcje
Inne
Ruthenium(II) piano stool coordination compounds with aminomethylphosphanes : synthesis, characterisation and preliminary biological study in vitro.
Autorzy
Rok wydania
2017
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
170
Strony
178-187
DOI
10.1016/j.jinorgbio.2017.02.017
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Reaction of {[Ru(η6-p-cymene)Cl]2(μ-Cl)2} (1) with aminomethylphosphane derived from morpholine (P{CH2N(CH2CH2)2O}3 (A), PPh2{CH2N(CH2CH2)2O} (B)) or piperazine (P{CH2N(CH2CH2)2NCH2CH3}3 (C), PPh2{CH2N(CH2CH2)2NCH2CH3} (D)) results in four new piano stool ruthenium(II) coordination compounds: [Ru(η6-p-cymene)Cl2(A)] (2A), [Ru(η6-p-cymene)Cl2(B)] (2B), [Ru(η6-p-cymene)Cl2(C)] (2C) and [Ru(η6-p-cymene)Cl2(D)] (2D). Every complex was fully characterized using spectroscopic methods (1H, 13C{1H}, 31P{1H} NMR and ESI-MS), elemental analysis, X-ray single crystal diffraction and DFT calculations. Preliminary studies of in vitro cytotoxicity on the A549 (human lung adenocarcinoma) and MCF7 (human breast adenocarcinoma) cell lines revealed 2A-2D activity in the same order of magnitude as in the case of cisplatin. Additionally, the study confirmed the ability of 2A-2D to interact with DNA helix and transferrin.
Słowa kluczowe
aminomethylphosphanes, cytotoxicity, organometallic chemistry, ruthenium
Adres publiczny
http://dx.doi.org/10.1016/j.jinorgbio.2017.02.017
Strona internetowa wydawcy
Podobne publikacje
Tertiary to secondary reduction of aminomethylphosphane derived from 1-ethylpiperazine as a result of its coordination to ruthenium(II) centre : the first insight into the nature of process.
Płotek Michał, Starosta Radosław, Komarnicka Urszula K., Skórska-Stania Agnieszka, Kołoczek Przemysław, Dudek Karol, Kyzioł Agnieszka
Dicationic ruthenium(II)–arene–curcumin complexes containing methylated 1,3,5–triaza-7-phosphaadamantane : synthesis, structure, and cytotoxicity.
Pettinari Riccardo, Condello Francesca, Marchetti Fabio, Pettinari Claudio P., Smoleński Piotr, Riedel Tina, Scopelliti Rosario, Dyson Paul J.
Interaction of ruthenium(II) and ruthenium(III) ions with 5-methyl-1,2,4-triazolo[1,5-α]pyrimidin-7(4H)-one.
Fandzloch Marzena, Wojtczak Andrzej, Sitkowski Jerzy, Łakomska Iwona
