Repozytorium
Wyszukaj
Kolekcje
Inne
Method of obtaining surfactin-stabilised poly(D,L-lactide) nanocarriers and nanocarriers prepared with this method
Autorzy
Rok wydania
Kolekcja
Język
Angielski
Typ publikacji
Patent
The subject of the invention is a method of obtaining surfactin-stabilised poly(D,L-lactide) carriers, characterized in that it comprises following steps: a) dissolution of poly(D,L-lactide) in organic solvent; b) interphase precipitation by dropwise addition of the organic phase obtained in step a) to aqueous surfactin solution within 1-5 minutes with continuous mixing of aqueous phase, wherein surfactin in aqueous solution is surfactin in the form of carboxylic acid or sodium salt; c) mixing until the polymer is precipitated; d) evaporation of organic solvent. Another subject of the invention are surfactin-stabilised poly(D,L-lactide) carriers obtained with the method according to invention, characterized in that they constitute spherical particles of hydrodynamic diameter from 125 to 200 and polydispersity index PDI<0.15.
