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Inne
Cobalt and zinc compounds bearing 1,10-phenanthroline-5,6-dione or 1,3,5-triaza-7-phosphaadamantane derivatives–synthesis, characterization, cytotoxicity, and cell selectivity studies.
Autorzy
Rok wydania
2013
Czasopismo
European Journal of Inorganic Chemistry
Strony
3651-3658
DOI
10.1002/ejic.201300197
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)2][BF4] (2, DION = 1,10-phenanthroline-5,6-dione), [Zn(DION)2]Cl2 (3) and [ZnCl(κO-PTA=O)(DION)][BF4] (4) were synthesized by reaction of CoCl2 with [mPTA]I or DION and ZnCl2 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far-IR, 1H, 13C and 31P{1H} NMR spectroscopy, ESI-MS, elemental analyses and single-crystal X-ray diffraction structural analysis (for 1). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.
Słowa kluczowe
Cobalt, zinc, N ligands, medicinal chemistry, Antitumor agents
Adres publiczny
http://dx.doi.org/10.1002/ejic.201300197
Strona internetowa wydawcy
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