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Biotransformations of bicyclic trimethylcyclohexane chloro-, bromo- and iodolactones using fungal strains.
Autorzy
Rok wydania
2010
Czasopismo
Biocatalysis and Biotransformation
Numer woluminu
28
Strony
408-414
DOI
10.3109/10242422.2010.538688
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Abstract Several fungal strains (Fusarium, Botrytis, Beauveria) were screened for their ability to transform three bicyclic halo-γ-lactones with a trimethylcyclohexane ring. Most of the micro-organisms carried out hydrolytic dehalogenation and transformed these lactones into two hydroxy-γ-lactones: cis (−)-2-hydroxy-4,4,6-trimethyl-9-oxabicyclo[4.3.0]nonan-8-one and trans (+)-2-hydroxy-4,4,6-trimethyl-9-oxabicyclo[4.3.0]nonan-8-one. The structures of all substrates and products were established on the basis of their spectral data and X-ray analysis. The method presented offers an alternative route to obtaining hydroxylactones with high enantiomeric excess.
Słowa kluczowe
lactones, biotransformations, hydrolytic, dehalogenation, fusarium species
Adres publiczny
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