Repozytorium
Wyszukaj
Kolekcje
Inne
Lactones 44. Microbial lactonization of γ-ketoacids.
Autorzy
Rok wydania
2014
Czasopismo
Journal of Molecular Catalysis B-Enzymatic
Numer woluminu
106
Strony
32-39
DOI
10.1016/j.molcatb.2014.04.014
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Enantiomerically pure γ-lactones ((+)-4a, (−)-5a, (+)-4b) have been obtained from the corresponding γ-ketoacids (3a and 3b) by their biotransformations with the three fungal strains: Rhodotorula glutinis AM242, Saccharomyces cerevisiae AM464 and Chaetomium sp. KCh6670. Microbial lactonization of 3,7-dimethyl-4-oxooctanoic acid (3a) with R. glutinis AM242 afforded the (+)-(4S,5R)-trans-γ-lactone (4a) with 99% ee, while Chaetomium sp. KCh6670 proved to be the best biocatalyst for the bioreduction and following lactonization of γ-ketoacid (3a), which afforded (−)-cis-γ-lactone (5a) with 99% ee. Biotransformation of 3,7,7-trimethyl-4-oxooctanoid acid (3b) in the culture of S. cerevisiae AM464 gave the corresponding (+)-trans-γ-lactone (4b) with 99% ee. The odours of the racemic γ-lactones ((±)-4a, (±)-5a, (±)-4b and (±)-5b) and optically pure isomers ((+)-4a, (−)-5a, (+)-4b) were evaluated.
Słowa kluczowe
Biotransformation, microbial lactonization, γ-Ketoacids, γ-Lactones
Adres publiczny
http://dx.doi.org/10.1016/j.molcatb.2014.04.014
Strona internetowa wydawcy
Podobne publikacje
Lactones 38: synthesis and odoriferous properties of p-menthane lactones.
Dams Iwona, Białońska Agata, Ciunik Zbigniew, Wawrzeńczyk Czesław
Microbial Baeyer-Villiger oxidation of steroidal ketones using Beauveria bassiana: presence of an 11α-hydroxyl group essential to generation of D-homo lactones.
Świzdor Alina, Kołek Teresa, Panek Anna, Białońska Agata
Synthesis, characterization, cytotoxicity, and antibacterial properties of trans-γ-halo-δ-lactones.
Kamizela Angelika, Gawdzik Barbara, Urbaniak Mariusz, Lechowicz Łukasz, Białońska Agata, Gonciarz Weronika, Chmiela Magdalena
